Course Content:
 
1. Introduction to Biosensors
Definition and significance of biosensors in various fields.
Historical development and evolution of biosensor technology.
Key components of biosensors: biological sensing element, transducer, and detector.
Overview of biosensor applications in healthcare, environmental monitoring, food safety, and biotechnology.
2. Basic Principles of Biosensor Functionality
Mechanisms of biosensing: recognition and transduction.
The role of bioreceptors (enzymes, antibodies, nucleic acids) in biosensor performance.
Signal generation and amplification in biosensors.
Importance of selectivity and sensitivity in biosensor design.
3. Types of Biosensors
Electrochemical biosensors: principles, types, and applications.
Optical biosensors: principles and advantages.
Piezoelectric biosensors: mechanisms and uses.
Thermal biosensors: operational principles and applications.
Comparison of different biosensor types regarding sensitivity, specificity, and applications.
4. Introduction to Optical Biosensors
Principles of optical sensing and its relevance in biosensing.
Different optical detection techniques: fluorescence, absorbance, and refractive index measurements.
Advantages of optical biosensors: real-time monitoring, high sensitivity, and label-free detection.
Key applications of optical biosensors in clinical diagnostics and environmental sensing.
5. Localized Surface Plasmon Resonance (LSPR) – Theory and Principles
Explanation of localized surface plasmon resonance and its significance in biosensing.
Interaction of light with metallic nanoparticles and the resulting optical phenomena.
Factors affecting LSPR: particle size, shape, and dielectric environment.
Applications of LSPR in detecting biomolecules at ultra-low concentrations.
6. Gold Nanoparticles in LSPR-Based Biosensors
Properties of gold nanoparticles and their role in enhancing biosensor sensitivity.
Methods for synthesizing gold nanoparticles and controlling their size and shape.
Functionalization of gold nanoparticles for specific biomolecule detection.
Case studies showcasing the use of gold nanoparticles in LSPR-based biosensors.
7. Applications and Case Studies of LSPR-Based Biosensors
Review of current research and advancements in LSPR biosensing technology.
Examples of successful LSPR-based biosensors in medical diagnostics (e.g., cancer biomarkers, infectious diseases).
Environmental monitoring applications: detection of pollutants and pathogens.
Future prospects and challenges in the field of LSPR-based biosensors.
8. Hands-On Examples/Calculations & Open Discussion
Practical demonstrations of LSPR biosensor setups and measurement techniques.
Step-by-step calculations for determining detection limits and sensor performance metrics.
Group discussion on potential improvements and innovations in biosensor technology.
Q&A session to address student inquiries and encourage collaborative learning.
 
On November 23rd and 24th, you will receive online training for six hours delivered by Ph.D. Abdullah Alakbarov